亚博电竞

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生命学院陶伟/李程与合作者揭示增强子调控细胞衰老相关分泌表型SASP的新机制

2020年10月12日,亚博电竞生命科学学院陶伟教授研究组、李程研究员研究组及合作者在Nucleic Acids Research在线发表了题为“”的研究论文。该研究探讨了染色质在细胞衰老过程中的空间变化规律,并阐释了拓扑结构域(TAD)结构内部由衰老活跃增强子介导的、通过招募转录因子C/EBPα 促进下游SASP基因表达的新型作用机制。­

fenmidanbaizhizushixibaoshuailaodebiaozhizhiyi,tashibutongzhongleixibaoyinzidebiaodahefenmimingxianzengjiadebiaoxing,yeshishuailaoxibaochanshengdezuizhongyaodehuanjingxiaoying,beichengweishuailaoxiangguandefenmibiaoxing(senescence-associated secretory phenotype,sasp)。sasptongchangbaokuoxibaoyinzi、quhuayinzi、shengzhangyinzihejizhijichudanbaimeideng。zheixieyinzitongguoyumianyixitongxiezuo,gaishanxibaoweihuanjingdetongshi,yingxianglinjinxibaodezengzhiyufenhua,duiqiguanshuailaohezhongliudefashengfazhanchanshengshuangxiangxingdediaokong,yinciyoubiyaoduishuailaoguochengzhongsaspdediaokongjizhidengwentijinxingshenrudetanjiu。

亚博电竞zheixianggongzuoliyonghi-cjishutanjiulexibaoshuailaodezao、zhonghewanqisangeshiqidednaxianghuzuoyongtupu,faxianxibaoshuailaozhongsanweiransezhidetadsquyuhetadsbianjieshiqingxiangyubaoshoude,danransetineibuheransetizhijiandnahuzuojulidediaokongfashenglemingxiandebianhua,jishuailaohouqidexibaocunzaigengduodeyuanduanjulidiaokongyugengshaodejinduanjulidediaokongfangshi。qiea/bgejianzaishuailaofashengshicunzaizhepinfandexianghuzhuanhuan,zaicigejianzhuanhuanguochengzhongxianzhuyingxianglezengqiangzidehuoxing。

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细胞衰老过程中活跃增强子调控SASP表达的机制模式图

亚博电竞yanjiurenyuanliyongh3k4me1heh3k27aczheiliangzhongteyixingbiaoshizengqiangzidezudanbaixiushi,miaohuileshuailaosangebutongshiqidezengqiangzifenbudongtaitu,bingzhongdianduih3k27acbiaoshidehuoyuezengqiangzijinxinglefenlei,faxianle2154gesuizheshuailaojinchengtuijin、h3k27acxinhaoqiangduzhujianjihuodeyileizengqiangzi——shuailaojihuoxiangguanzengqiangzi(senescence-activated enhancers,saes)。zaiduizheileisaejinxingfenxishi,yanjiurenyuanfaxian,saeszongshiqingxiangyufenbuzaibuhuoyueransezhigejianbxianghuoyueransezhigejianadezhuanhuanguochengzhong,qiesaesfujindejiyinzhuyaoyuxibaonianzhe、baowaixinhaoxiangying、diaokongbaijiesushengcheng、xibaoshuailaodengsaspdexingchengxinhaomibukefen。moti(motif)fenxixianshi,c/ebpjiazuteyixingfujizaisaesshang,suizheshuailaojinchengdejiakuai,c/ebpαdejiehesaesquyudeqiangduhuimingxianshenggao。tamentongguoyichuanxueshouduanduic/ebpαdebiaodajinxingganyushi,faxianc/ebpαhuixianzhuyingxiangsaesdefengdujiqifujinsaspjiyindebiaodayuxiayouyinzidefenmi。ciwai,saesqingxiangyuchengcujujizaitadneibu,tadkongjianshangxianzhilesaesdiaokongneibudejiyin。gaiyanjiutuozhanleransezhikongjianjiegouzhongsaspjiyinbiaodadiaokongdexinguilv,yejiangyouzhuyuchanmingsaspfahuiqingchushuailaoxibaogongnengganyushuailaojinchengdewenti,weixiayibuyiyaowushouduanganyusaspxinhaotujing、zhiliaozhongliuheshuailaoxiangguanjibingtigonglexindeyanjiufangxiang。

yabodianjingshengmingkexuexueyuanboshishengguanyitingheyabodianjingshengmingkexuexueyuan2016jiptnxiangmuboshishengzhangchaoweiwenzhangdebingliediyizuozhe。taowei、lichengheshoudouyikedaxuejichuyixueyuanzhangchenjiaoshouweiwenzhangdegongtongtongxunzuozhe。yabodianjingboshishenglvguoliang、huangxiaoke、zhangxuebin、zhuangtenghan、boshihoujialumengyijishengmingxueyuanzhanglijunfujiaoshoucanyuleyanjiugongzuo。gaiyanjiudedaoguojiazirankexuejijinhekejibuzhongdianyanfajihuadezizhu。

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